A standardized herbal extract mitigates tumor inflammation and augments chemotherapy effect of docetaxel in prostate cancer | Scientific Reports

Activation of the NFκB pathway is often associated with advanced cancer and has thus been regarded as a rational therapeutic target. Wedelia chinensis is rich in luteolin, apigenin, and wedelolactone that act synergistically to suppress androgen receptor activity in prostate cancer. Interestingly, our evaluation of a standardized Wedelia chinensis herbal extract (WCE) concluded its efficacy on hormone-refractory prostate cancer through systemic mechanisms. Oral administration of WCE significantly attenuated tumor growth and metastasis in orthotopic PC-3 and DU145 xenografts. Genome-wide transcriptome analysis of these tumors revealed that WCE suppressed the expression of IKKα/β phosphorylation and downstream cytokines/chemokines, e.g., IL6, CXCL1, and CXCL8. Through restraining the cytokines expression, WCE reduced tumor-elicited infiltration of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs) and endothelial cells into the tumors, therefore inhibiting angiogenesis, tumor growth, and metastasis. In MDSCs, WCE also reduced STAT3 activation, downregulated S100A8 expression and prevented their expansion. Use of WCE in combination with docetaxel significantly suppressed docetaxel-induced NFκB activation, boosted the therapeutic effect and reduced the systemic toxicity caused by docetaxel monotherapy. These data suggest that a standardized preparation of Wedelia chinensis extract improved prostate cancer therapy through immunomodulation and has potential application as an adjuvant agent for castration-resistant prostate cancer.
— Read on www.nature.com/articles/s41598-017-15934-0

Author: GreatCosmicMothersUnited

I have joined with many parents affected with the surreal , yet accepted issue of child abuse via Pathogenic Parenting / Domestic abuse. As a survivor of Domestic Abuse, denial abounded that 3 sons were not affected. In my desire to be family to those who have found me lacking . As a survivor of psychiatric abuse, therapist who abused also and toxic prescribed medications took me to hell on earth with few moments of heaven. I will share my life, my experiences and my studies and research.. I will talk to small circles and I will council ; as targeted parents , grandparents , aunts , uncles etc. , are denied contact with a child for reasons that serve the abuser ...further abusing the child. I grasp the trauma and I have looked at the lost connection to a higher power.. I grasp when one is accustomed to privilege, equality can feel like discrimination.. Shame and affluence silences a lot of facts , truths that have been labeled "negative". It is about liberation of the soul from projections of a alienator , and abuser ..

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