A new study published in the Journal of Affective Disorders Reports sheds light on the profound and often devastating effects of antidepressant withdrawal. Led by Joanna Moncrieff of University College London, the research found that 80% of participants withdrawing from antidepressants experienced moderate to severe impacts on their lives, including disrupted work, strained relationships, and even the loss of jobs. Alarmingly, 40% of participants reported symptoms lasting more than two years, while 25% were unable to stop taking antidepressants altogether.
The findings reignite an ongoing debate in psychiatry about the nature of antidepressant withdrawal. Critics have long argued that post-withdrawal symptoms are often mistaken for a relapse of underlying conditions, but this study challenges that narrative by introducing the Discriminatory Antidepressant Withdrawal Symptom Scale (DAWSS). The DAWSS identifies 15 symptoms that are most likely caused by antidepressant withdrawal rather than pre-existing mental health issues.
As the authors note:
“Half the participants in our study who had stopped antidepressants had experienced withdrawal symptoms that lasted for over a year, around a third for more than two years and 10% for more than five years. Impairment of the ability to work was common, including having to reduce hours, take sick leave or stop work altogether. Family and relationship problems and having to give up social activities were also frequently reported. Free text answers revealed that some people had suffered significant disability and distress.”
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